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单细胞基因检测和转染纳米芯片线上学术报告

2020-3-25     浏览量 480

报告主题:单细胞基因检测和转染纳米芯片
主讲人:常凌乾 教授
报告时间:2020/03/26 19:00-20:00

点击链接直接加入会议:
https://meeting.tencent.com/s/5a5xQRS76a356

会议 ID:463 218 623

个人简介:
常凌乾,博士,现为北航生物与医学工程学院教授,东南学者,博士生导师,单细胞工程研究所负责人。致力于生物医学芯片技术的研究和教学工作,研究聚焦在生物医学微纳米器件、微流控技术、基因转染芯片、细胞传感器等。博士毕业于美国俄亥俄州立大学,曾于美国北德克萨斯大学担任Tenure-Track助理教授。
正在承担北京市生物医学工程高精尖中心——单细胞工程研究所项目等。近五年发表SCI论文50篇,如Nature Nanotechnology, Nano Letters,Small等,4篇入选ESI高被引论文;论文总被引1400余次,H指数21(谷歌学术),并被Science Translational Medicine、Chemical Review等顶级期刊亮点或专题报道。申请和授权中国专利5项,美国专利3项;主编英文专著1部(Springer Nature出版),兼任多个SCI期刊的副主编和编委。
获得2018年微系统与纳米工程国际会议青年科学家奖,2016年俄亥俄州立大学博士最高奖Presidential Fellowship(800名博士,10人获奖)等奖励。

Abstract

One of the cutting-edge multidisciplinary research themes in Biomedical Engineering is to design and manufacture advanced Bio-Chip for life science, ranging from in vitro cell biology toward in vivo medicine. In recent years, nanotechnologies facilitate the development of bio-chips and devices which have demonstrated unprecedented capabilities in single cell analysis and manipulation.
In this talk, we will introduce a novel nano-biotechnology, nano-electroporation (NEP) for cellular gene transfection, interrogation and therapy. The nanotechnology allows for high-throughput, and precisely delivery of gene / drugs into living cells at single-cell resolution. The in vitro applications of the NEP device have been demonstrated in the studies of intracellular cancer biomarker heterogeneity in leukemic cells, cardiomyocytes, T lymphocytes and glioma stem cells. Our latest efforts have achieved in vivo cell reprogramming for on-body gene therapy and wound healing. Currently, we are also working on flexible wearable nanotransfection device with the specific aims on locally gene editing and therapy.

欢迎感兴趣的老师以及研究生,高年级的本科生参加!
主办单位:安徽医科大学 生物医学工程学院